Duvelisib (PI3K Delta/PI3K Gamma Inhibitor)

Clinical Trials

Preclinical/Scientific

Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration

The unique functions of PI3Kγ in malignant B cells in CLL.

Defactinib (FAK/PYK2 Inhibitor)

Solid Tumors

Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

Defactinib’s sensitivity determined by merlin deficiency

Of General Interest

Hallmarks of Cancer: The Next Generation

Targeting the tumor microenvironment